Earthquakes have the potential to cause widespread destruction, especially in urban areas with high infrastructure and population density. Understanding and analyzing urban earthquake vulnerability is crucial for reducing the impact of earthquakes. Earthquake hazard zoning plays a significant role in assessing urban earthquake vulnerability. By dividing a region into different zones based on earthquake hazard levels, authorities can prioritize resources and implement targeted mitigation measures. In this regard, the vulnerability assessment of different areas in the city of Shiraz has been studied. The present research is of a practical nature, and its investigation has been conducted using a descriptive-analytical method. In order to achieve the research objectives, the effective criteria for urban tissue vulnerability to earthquakes (physical and environmental factors, land morphology, access to emergency and medical centers, and proximity to hazardous facilities) were first identified. Then, using the Analytic Network Process (ANP) model and its software, the value and importance of each criterion were determined. In the next stage, the results of the network analysis process with 4 criteria and 21 sub-criteria were combined, and a map of the level of vulnerability of urban tissues in Shiraz was prepared. The research results indicate that among the influential criteria, physical and environmental factors received the highest score, and the central and southwestern urban areas have the highest vulnerability to earthquakes in the city of Shiraz.